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- DOI 10.18231/2581-3706.2018.0031
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CrossMark
- Citation
Relation of alcohol to Helicobacter pylori infection: A cross sectional study
- Author Details:
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Rakshitha HB
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Amita K
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Mangala Gouri
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Avinash Balekuduru
Introduction: H. pylorus is found in half the population of the world. Worldwide, H. pylorus is by far the most common aetiological agent for non self-limiting gastritis. Socioeconomic conditions in childhood is identified as a major risk factor for infection. Many studies have been conducted to establish the association of alcohol consumption and H Pylori gastritis, however the results reported by these studies were inconsistent.
Need of the present study is to assess the relation of alcohol consumption to H. pylori infection.
Objective: To assess the proportion of H. pylori and atrophic gastritis in alcoholic patients with upper gastrointestinal symptoms.
Materials and Methods: A prospective study was conducted from October 2013 to June 2015 in the Department of Gastroenterology, M.S. Ramaiah Hospitals (M.S. Ramaiah Teaching Hospital and M.S. Ramaiah Memorial Hospital), Bangalore. 150 alcoholic patients were involved in the study. Age, sex, presenting complaints and detailed history regarding alcohol intake was taken. Rapid urease test was done for all the patients and a gastric biopsy sample was obtained from the antrum of the stomach and sent to the pathology department. Sections made from the gastric biopsy sample were stained with H and E and Giemsa stain. Sections were then evaluated for the presence of H. pylori.
Results: In the 150 alcoholic patients included in the study, prevalence of H. pylori was 76%. The age and the gender did not play a role in the H. pylori infection. It was observed in the study that the prevalence of H. pylori infection increased with the increase in frequency, duration, amount of alcohol intake with a statistically significant p value. It was found that the consumption of spirit was associated more with H. pylori positivity than beer intake.
Conclusion: The prevalence of H. pylori infection increases with the increase in frequency, duration and quantity of alcohol intake. The type of alcohol consumed also plays a role in H. pylori infections.
Keywords: H. pylori, Alcohol intake, Gastric biopsy.
References
- Correa P. The epidemiology and pathogenesis of chronic gastritis: three etiologic entites. Journal of Gastrointestinal Research 1980;6:98–08.
- Graham DY. Helicobacter pylori infection in the pathogenesis of duodenal ulcer and gastric cancer: a model. Gastroenterology. 1997;113:1983–91.
- Schistosomes, liver flukes and Helicobacter pylori. IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. 1994;61:1–41.
- Uemura N, Okamoto S, Yamamoto S. Helicobacter pylori infection and the development of gastric cancer. New England Journal of Medicine. 2001;345:784–9.
- Kalantar J, Eslick GD, Talley NJ. Chronic gastritis and nonulcer dyspepsia. Current Topics in Microbiology and Immunology. 1999;241:31–5.
- Talley NJ, Li Z. Helicobacter pylori: testing and treatment. Expert Rev Gastroenterology and Hepatology. 2007;1:71–9.
- Eslick GD, Lim LL-Y, Byles JE. Association of Helicobacter pylori infection with gastric carcinoma: a meta-analysis. American Journal of Gastroenterology. 1999;94:2373–9.
- Hunt RH, Xia SD, Megraud F, Leon-Barua R, Bazzori F, Vander Merwe S et al. Helicobacter pylori in Developing countries. World Gastroenterology Organisation Global guideline. Journal of Gastrointestinal and liver Disease. 2011;45:383-8.
- Zhang, L, Guy D, Eslick, Harry H.-X. Xia, Chengqiu Wu, NghiPhung, Nicholas J. Talley. Relationship between alcohol consumption and active Helicobacter pylori infection. Alcohol and Alcoholism. 2010;45:89-94.
- Brenner H, Rotherbacher D, Bode G, Adler G. Inverse graded relation between alcohol consumption and active infection with Helicobacter pylori. American Journal of Epidemiology. 1999;149:571-6.
- Ogihara, A. Relationship between Helicobacter pylori infection and smoking and drinking habits. Journal of Gasteroenterology and Hepatology. 2000;15:271-6.
- Murray LJ, Lane AJ, Harvey IM, Donovan JL, Nair P, Harvey RF. Inverse relationship between alcohol consumption and active Helicobacter infection: the Bristol Helicobacter project. American Journal of Gastroenterology. 2002;97:2750-5.
- Kuepper-Nybelen J, W. Thefeld, D. Rothenbacher, Brenner H. An inverse relation between alcohol consumption and H. pylori infection. Alimentary Pharmacology and Therapeutics 2005;21:57-64.
- Rosenstock SJ, Jorgensen T, Andersen LP. Association of Helicobacter pylori infection with lifestyle, chronic disease, body indicesand age at menarche in Danish adults. Journal of Public Health. 2000;28:32–40.
- Ito LS, Oba SM, Hamajima N et al. Helicobacter pylori seropositivity among 963 Japanese Brazilians according to sex, age, generation, and lifestyle factors. Japan Journal of Cancer Research. 2001;92:1150–6.
- Moayyedi P, Axon ATR, Feltbower R. Relation of adult lifestyle and socio-economic factors to the prevalence of Helicobacter pylori infection. International Journal of Epidemiology. 2002;31:624-31.
- Brenner H, Bode G, Adler G, Hoffmeister A, Koeniq W, Rothenbacher D. Alcohol as a gastric disinfectant? The complex relationship between alcohol consumption and current Helicobacter pylori infection. Epidemiology. 2001;12:209-14.
- Gikas A, Triantafillidis JK, Apostolidis N et al. Relationship of smoking and coffee and alcohol consumption with seroconversion to Helicobacter pylori: a longitudinal study in hospital workers. Journal of Gastroenterology and Hepatology. 2004;19:927–33.
- Riezzo G, Chiloiro M, Montanaro S. Protective effect of amtolmetinguacyl versus placebo diclofenac and misoprostol in healthy volunteers evaluated as gastric electrical activity in alcohol-induced stomach damage. Journal of Digestive Science. 2001;46:1797–804.
- Bode C, Bode JC. Alcohol’s role in gastrointestinal tract disorders. Alcohol Health Research World. 1997;21:76-3.
- Bode JC, Bode C. Alcohol malnutrition and the gastrointestinal tract. Nutrition and Alcohol. 1992;48:403–28.
- Bode C, Maute G, Bode JC. Prostaglandin E2 and prostaglandin F2α biosynthesis in human gastric mucosa: effect of chronic alcohol misuse. Gastroenterology. 1996;39:348–52.
- Jones GW. The attachment of bacteria to the surface of animal cells. Microbial Interaction. London: Chapman & Hall. 1977; 139–76.
- Rad R, Gerhard M, Lang R et al. The Helicobacter pylori blood group antigen-binding adhesin facilitates bacterial colonization and augments a nonspecific immune response. Journal of Immunology. 2002;168:3033–41.
- Ilver D, Arnqvist A, Ogren. Helicobacter pylori adhesion binding fucosylatedhisto-blood group antigens revealed by retagging. Science. 1998;79:373-5.
- Mahdavi J, Sonden B, Hurtig Met. Helicobacter pylori Sab Aadhesin in persistent infection and chronic inflammation. Science. 2002;97:573-8.
- Yamaoka Y, Kwon DH, Graham DY. Proinflammatoryouter membrane protein (oipA) of Helicobacter pylori. National Academy of Science. 2000;97:7533–8.
- Yamaoka Y, Kikuchi S, Zimaity HM. Importance of Helicobacter pylori oipA in clinical presentation, gastric inflammation, and mucosal interleukin 8 production. Gastroenterology. 2002;123:414–24.
How to Cite This Article
Vancouver
HB R, K A, Gouri M, Balekuduru A. Relation of alcohol to Helicobacter pylori infection: A cross sectional study [Internet]. IP J Diagn Pathol Oncol. 2018 [cited 2025 Oct 19];3(3):145-149. Available from: https://doi.org/10.18231/2581-3706.2018.0031
APA
HB, R., K, A., Gouri, M., Balekuduru, A. (2018). Relation of alcohol to Helicobacter pylori infection: A cross sectional study. IP J Diagn Pathol Oncol, 3(3), 145-149. https://doi.org/10.18231/2581-3706.2018.0031
MLA
HB, Rakshitha, K, Amita, Gouri, Mangala, Balekuduru, Avinash. "Relation of alcohol to Helicobacter pylori infection: A cross sectional study." IP J Diagn Pathol Oncol, vol. 3, no. 3, 2018, pp. 145-149. https://doi.org/10.18231/2581-3706.2018.0031
Chicago
HB, R., K, A., Gouri, M., Balekuduru, A.. "Relation of alcohol to Helicobacter pylori infection: A cross sectional study." IP J Diagn Pathol Oncol 3, no. 3 (2018): 145-149. https://doi.org/10.18231/2581-3706.2018.0031