Study of prevalence of haemoglobin disorders in sindhi community with reference to HPLC

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Original Article

Author Details : Rajan S. Bindu, Ashok K. Methwani, Anuradha R. Bindu, Preetinanda M. Dash

Volume : 3, Issue : 2, Year : 2018

Article Page : 110-117

https://doi.org/10.18231/2581-3706.2018.0024

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Abstract

Introduction: Inherited haemoglobin disorders are major health problems in certain communities in different geographical areas in India. These disorders pose a huge burden on affected families physically, financially & psychologically. This study is carried out to find the Prevalence of these disorders in Sindhi community in Aurangabad city in state of Maharashtra, India.
Materials and Methods: The present cross-sectional study was undertaken among 338, apparently healthy Sindhi individuals from community in Aurangabad, Maharashtra from July 2014 to March 2017. All the samples were tested in automated hematology cell counter and then for HPLC on Bio-Rad variant classic. Various CBC parameters and Hemoglobin patterns were derived on all samples.
Result: The overall prevalence of Hemoglobinopathy was 60/338 (17.75%), comprised of 42 (12.42%) cases of BTT, 3 (0.88%) cases of BTM, 3 (0.88%) cases of SCT, 11 (3.25%) cases of Hb Q-India & One (0.29%) case of Hb Q-India+BTT.
Conclusion: Out of 338 samples, BTT and Hb Q-India were found to be more common Hb disorders in Sindhi community. Screening of community and counselling regarding the nature of these disorders are very important measures to reduce the burden of disease.

Keywords: Hemoglobin disorders, Prevalence, HPLC, β-thalassemia trait, Hb Q-India, Maharashtra, India.

How to cite : Bindu R S, Methwani A K, Bindu A R, Dash P M, Study of prevalence of haemoglobin disorders in sindhi community with reference to HPLC. IP J Diagn Pathol Oncol 2018;3(2):110-117

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