Peripheral hemophagocytosis- A key to decifer hemophagocytic lymphohistiocytosis, an extremely rare case report


Case Report

Author Details : Swati Raj*

Volume : 9, Issue : 4, Year : 2024

Article Page : 224-229

https://doi.org/10.18231/j.jdpo.2024.046



Suggest article by email

Get Permission

Abstract

Abstract

Hemophagocytic lymphohistiocytosis(HLH) is an uncommon and probably underdiagnosed disorder that requires quick medical attention because of its high and rapid mortality rate. The present criteria are the only ones used to diagnose HLH. For a laboratory diagnosis of HLH-2007(an upgraded version of HLH-2004), five of the eight requirements must be satisfied. We report an exceedingly rare case of a thirty-year-old Indian man who has been clinically presenting with a high-grade fever, weakness, oligouria, and speech slurring for 20 days. While screening peripheral blood smear(PBS) in order to correct complete blood counts, peripheral circulating hemophagocytic histiocytes were identified and further testing was advised as suspicion of HLH was taken into account. Our case fulfilled the WHO 2009 diagnostic criteria of HLH, hence a diagnosis of Hemophagocytic Lymphohistiocytosis was awarded. To the best of our knowledge, no HLH case has ever been recorded in India based on suspicion raised by PBS findings. Globally, only six similar cases of HLH with peripheral findings have been posted online.


Keywords: ­Histiocytes, Hemophagocytic Lymphohistiocytosis, Peripheral Blood Smear, HLH Diagnostic Criteria


How to cite : Raj S, Peripheral hemophagocytosis- A key to decifer hemophagocytic lymphohistiocytosis, an extremely rare case report. IP J Diagn Pathol Oncol 2024;9(4):224-229


This is an Open Access (OA) journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.







Article History

Received : 10-09-2024

Accepted : 04-11-2024


View Article

PDF File   Full Text Article


Copyright permission

Get article permission for commercial use

Downlaod

PDF File   XML File   ePub File


Digital Object Identifier (DOI)

Article DOI

https://doi.org/ 10.18231/j.jdpo.2024.046


Article Metrics






Article Access statistics

Viewed: 226

PDF Downloaded: 66