Comparison of proliferative potential in variants of ossifying fibroma (OF) of craniofacial complex

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Original Article

Author Details : Savita Wagh, Mandakini S Mandale, Jayanti G Humbe, Vaishali A Nandkhedkar, Poonam R Zanwar*, Nidhi Kaushal

Volume : 9, Issue : 4, Year : 2024

Article Page : 215-219

https://doi.org/10.18231/j.jdpo.2024.044

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Abstract

Abstract

Aim: Comparison of proliferative potential in JTrOF , PsOF and OF of craniofacial complex using CDK4 and pHH3.
Introduction: Fibro-osseous lesions (FOL) refers to a poorly defined diverse group of lesions affecting the jaws and craniofacial complex. This spectrum of lesions includes fibrous dysplasia, cement-osseous dysplasia and two histological variants of ossifying fibroma - Despite benign neoplasms, both the variants of ossifying fibroma are characterized by rapid growth, potential for local invasiveness and a tendency to recur. According to the literature, the recurrence rate of JTrOF is about 20% where as PsOF is from 30-56%. Diagnosis is based on histopathology and imaging of the lesion. Early diagnosis allows for the resection of a smaller lesion , reducing the chance of damage to nearby structures. Various biomarkers such as oncogenes CDK4, MDM2, p53 and ?-SMA have been investigated in bone pathology to predict biological behaviour of these lesions for precise treatment planning.
Materials and Methods: Immunohistochemical expression of CDK4 and pHH3 will be assessed in histopathological diagnosed cases of juvenile trabecular ossifying fibroma, psammamatoid ossifying fibroma and conventional ossifying fibroma.
Results: The immunohistochemical expression of CDK4 was 100% in JTrOF and PsOF and 60% in OF. The expression of pHH3 was weak and focal in JTrOF and PsOF and also weak in OF.
Conclusion: This study reveals the genetic mechanism involved in pathogenesis of aggressive variant of OF. Pre-treatment biopsy and CT scan are necessary for proper diagnosis and treatment planning of the lesion.

Keywords: Juvenile Ossifying Fibroma, PHH3 CDK4, Ossifying Fibroma

How to cite : Wagh S, Mandale M S, Humbe J G, Nandkhedkar V A, Zanwar P R, Kaushal N, Comparison of proliferative potential in variants of ossifying fibroma (OF) of craniofacial complex. IP J Diagn Pathol Oncol 2024;9(4):215-219

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