Ovarian myeloid sarcoma with concurrent acute myeloid leukemia- A case report

---

Case Report

Author Details : Brijesh Thakur*, Seema Acharya, Sucheta Bansal, Priti Mishra

Volume : 8, Issue : 4, Year : 2023

Article Page : 237-240

https://doi.org/10.18231/j.jdpo.2023.056

Suggest article by email

Get Permission

---

Abstract

Myeloid sarcoma is a rare extramedullary tumor of immature myeloid cells that can be composed of cells showing granulocytic or monocytic differentiation. It is frequently detected as masses in subcutaneous soft tissue, bone, skin, GIT, reproductive organs, CNS, heart, lungs, kidney and breast. We report a pediatric case of myeloid sarcoma presenting with bilateral ovarian masses.
A 12 years old female presented with complaints of fever, lethargy, decreased appetite and easy fatiguability. Patient further developed swelling and pain in large joints along with slurring of speech and difficulty in swallowing. Examination revealed polyserositis along with hepatosplenomegaly. ANA IFA profile was positive. CECT abdomen showed heterogeneous lesions in bilateral adnexae along with a few enlarged matted lymph nodes in left para-aortic region (?Neoplastic/ ?Histiocytosis/ ?EM hematopoiesis). GBP was suggestive of leucoerythroblastic reaction. BM study with flowcytometry was suggestive of Acute myeloid leukemia with monocytic differentiation. Biopsy from both adnexae showed features consistent with poorly differentiated malignancy, favour haematolymphoid neoplasm. Immunophenotyping by IHC showed the cells to be positive for CD45 (dim), MPO & CD117, thus establishing diagnosis of Myeloid sarcoma, both ovaries.
Myeloid sarcoma is uncommon ovarian neoplasm and the clinical presentation may be with or without acute leukemia / MPN. Immunohistochemistry and ancillary studies are necessary to recognize this entity.
 

Keywords: Child, Flowcytometry, IHC, Myeloid sarcoma, Ovary

How to cite : Thakur B, Acharya S, Bansal S, Mishra P, Ovarian myeloid sarcoma with concurrent acute myeloid leukemia- A case report. IP J Diagn Pathol Oncol 2023;8(4):237-240

This is an Open Access (OA) journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.