Clinicopathological profile of triple negative breast cancer in a tertiary health care centre of India

---

Original Article

Author Details : Gulshan Patel, Saqib Ahmed*, Ruhi Hasan, Mahboob Hasan

Volume : 8, Issue : 3, Year : 2023

Article Page : 137-140

https://doi.org/10.18231/j.jdpo.2023.032

Suggest article by email

Get Permission

---

Abstract

Introduction: Breast carcinoma is one of the most common malignancies affecting women in developing countries. It is divided into several subtypes, including triple negatives. TNBCs are found to have an aggressive behaviour and have a metastasic potential leading to an overall poorer prognosis.
Aims and Objective: The aim was to study the clinicopathological profile of TNBC pateints including parameters like age, site, tumour size, histopathological type, histologic grade, lymphovascular invasion and nodal invasion and TNM Staging was done to study the overall prognosis.
Materials and Methods: A four year retrospective study was conducted on ninety seven cases of breast carcinoma which were further classified based on immunohistochemical staining into four subtypes. The clinicopathological details and the histomorphological features of these patents were studied.
Results: Of the 208 cases, 97 cases were diagnosed as TNBC. The average age at presentation was 45 years. Most of the cases showed Nottingham Modification of Scarff Bloom-Richardson (NMBR) grade 3 (66%) and stage II (50.7%). Lymph node metastasis and Lymphovascular invasion was seen in 62% and 24.7% of cases. Infiltrating ductal carcinoma (not otherwise specified) type (94.8%) was the most common histological type.
Conclusion: TNBC have an aggressive behaviour compared to other subtypes with higher SBR grade. Lymphovascular invasion and nodal metastasis.
 

Keywords: Aggressive behaviour, Estrogen receptor, Her2­Neu, Progesterone receptor

How to cite : Patel G, Ahmed S, Hasan R, Hasan M, Clinicopathological profile of triple negative breast cancer in a tertiary health care centre of India. IP J Diagn Pathol Oncol 2023;8(3):137-140

This is an Open Access (OA) journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.