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- DOI 10.18231/j.jdpo.2025.020
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CrossMark
- Citation
Coexistence of follicular variant of papillary thyroid carcinoma and oncocytic adenoma on the background of Hashimoto’s thyroiditis: Case report
- Author Details:
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Vaanika Kaira
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Jocelyn Sara Paul
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Vibha R Vyas *
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Majal Shah
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Isha Sharma
Papillary thyroid carcinoma (PTC) is the most common histologic type of thyroid cancer comprising of 80–90% of all subtypes with female predominance. Hashimoto’s thyroiditis (HT), also synonymous with chronic autoimmune thyroiditis and chronic lymphocytic thyroiditis, is an autoimmune disease characterized by immune destruction of thyroid cells mediated via cell and antibody dependant immune processes. Dailey et al. first described the association between PTC and HT in 1955. Approximately 30% of PTC have HT in their background. Several studies have reported HT as a risk factor for the development of PTC. Oncocytic adenomas (OA) comprise 10-15% of thyroid nodules and more common in men. We are reporting this case of 29 year old female having multifocal infiltrative follicular variant of PTC and Oncocytic adenoma with marked cytological atypia in the background of HT as it is very rare to encounter this coexistence except in the context of tumour syndromes.
Keywords: Papillary carcinoma, Oncocytic, Adenoma, Hashimoto’s thyroiditis.
References
- Liang J, Zeng W, Fang F, Yu T, Zhao Y, Fan X, et al. Clinical analysis of Hashimoto thyroiditis coexistent with papillary thyroid cancer in 1392 patients. Acta Otorhinolaryngol Ital. 2017;37(5):393-400.
- Avgoustou C. Avgoustou E. Coexistence of Hashimoto’s thyroiditis and papillary thyroid carcinoma. Hellenic J Surg. 2017;89(2):73–8.
- Battistella E, Pomba L, Costantini A, Scapinello A, Toniato A. Hashimoto's Thyroiditis and Papillary Cancer Thyroid Coexistence Exerts a Protective Effect: a Single Centre Experience. Indian J Surg Oncol. 2022;13(1):164–68.
- Gimm O. Thyroid cancer. Cancer Lett. 2001;163(2):143–56.
- Repplinger D, Bargren A, Zhang YW, Adler JT, Haymart M, Chen H. Is Hashimoto's thyroiditis a risk factor for papillary thyroid cancer? J Surg Res. 2008;150(1):49–52.
- Siegel RL, Miller KD, Jemal A. Cancer statistics, 2015. CA Cancer J Clin. 2015;65(1):5–29.
- Jiwang L, Zhendong L, Shuchun L, Bo H, Yanguo L. Clinicopathologic characteristics of familial versus sporadic papillary thyroid carcinoma. Acta Otorhinolaryngol Ital. 2015;35:234–42
- Cho BY, Choi HS, Park YJ, Lim JA, Ahn HY, Lee EK. et al. Changes in the clinicopathological characteristics and outcomes of thyroid cancer in Korea over the past four decades. Thyroid. 2013;23(7):797–804.
- Vanderpump MP, Tunbridge WM, French JM, Appleton D, Bates D, Clark F, et al. The incidence of thyroid disorders in the community: a twenty-year follow-up of the Whickham Survey. Clin Endocrinol (Oxf). 1995;43(1):55–68.
- Wong KS, Angell TE, Barletta JA, Krane JF. Hurthle cell lesions of the thyroid: Progress made and challenges remaining. Cancer Cytopathol. 2021;129(5):347–62.
- Dahl LD, Myssiorek D, Heller KS. Hurthle cell neoplasms of the thyroid. Laryngoscope. 2002;112(12):2178–80.
- Elliott DD, Pitman MB, Bloom L, Faquin WC. Fine-needle aspiration biopsy of Hurthle cell lesions of the thyroid gland: A cytomorphologic study of 139 cases with statistical analysis. Cancer. 2006;108(2):102–9.
- Harach HR, Soubeyran I, Brown A, Bonneau D, Longy M. Thyroid pathologic findings in patients with Cowden disease. Ann Diagn Pathol. 1999;3(6):331-40.
- Stratakis CA, Courcoutsakis NA, Abati A, Filie A, Doppman JL, Carney JA, et al. Thyroid gland abnormalities in patients with the syndrome of spotty skin pigmentation, myxomas, endocrine overactivity, and schwannomas (Carney complex). J Clin Endocrinol Metab. 1997;82(7):2037–43.
- Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394–424.
- Liu S, Semenciw R, Ugnat AM, Mao Y. Increasing thyroid cancer incidence in Canada, 1970–1996: time trends and age-period-cohort effects. Br J Cancer. 2001;85(9):1335–9.
How to Cite This Article
Vancouver
Kaira V, Paul JS, Vyas VR, Shah M, Sharma I. Coexistence of follicular variant of papillary thyroid carcinoma and oncocytic adenoma on the background of Hashimoto’s thyroiditis: Case report [Internet]. IP J Diagn Pathol Oncol. 2025 [cited 2025 Oct 07];10(2):87-89. Available from: https://doi.org/10.18231/j.jdpo.2025.020
APA
Kaira, V., Paul, J. S., Vyas, V. R., Shah, M., Sharma, I. (2025). Coexistence of follicular variant of papillary thyroid carcinoma and oncocytic adenoma on the background of Hashimoto’s thyroiditis: Case report. IP J Diagn Pathol Oncol, 10(2), 87-89. https://doi.org/10.18231/j.jdpo.2025.020
MLA
Kaira, Vaanika, Paul, Jocelyn Sara, Vyas, Vibha R, Shah, Majal, Sharma, Isha. "Coexistence of follicular variant of papillary thyroid carcinoma and oncocytic adenoma on the background of Hashimoto’s thyroiditis: Case report." IP J Diagn Pathol Oncol, vol. 10, no. 2, 2025, pp. 87-89. https://doi.org/10.18231/j.jdpo.2025.020
Chicago
Kaira, V., Paul, J. S., Vyas, V. R., Shah, M., Sharma, I.. "Coexistence of follicular variant of papillary thyroid carcinoma and oncocytic adenoma on the background of Hashimoto’s thyroiditis: Case report." IP J Diagn Pathol Oncol 10, no. 2 (2025): 87-89. https://doi.org/10.18231/j.jdpo.2025.020