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- DOI 10.18231/j.jdpo.2025.015
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CrossMark
- Citation
A cross-sectional study of clinicopathological patterns in leprosy patients in a tertiary care centre
- Author Details:
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Shivani Pravinchandra Parmar *
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Shashikant Mavadiya
Introduction: Mycobacterium leprae is the causative agent of leprosy, a persistent infectious granulomatous disease. 53.6% of newly reported cases worldwide each year still originate in India. The skin and peripheral nerves are the primary areas affected by leprosy. It can manifest in a variety of clinical and histological ways, contingent upon the host's cellular immunological response. Accurate leprosy diagnosis and type depend on histopathological analysis and the presence of lepra bacilli.
Aim: The objective is to evaluate the clinicopathological association between leprosy lesions.
Materials and Methods: Twenty skin biopsy specimens from patients with a clinical diagnosis of leprosy were the subject of a three-month cross-sectional investigation at the Pathology Department of SBKS Medical College and Research Institute, Piparia, Vadodara. Clinicohistopathological correlation was performed after skin biopsies were collected, processed, and stained with H&E stain and Fite-faraco stain to identify histopathological forms of leprosy.
Results: The age range of 41–60 years old accounted for the majority of cases in this study (45%). The ratio of men to women was 1.5:1. The most prevalent kind was borderline tuberculoid leprosy (8 cases, 40%), which was followed by lepromatous leprosy (4 instances, 20%). All instances of lepromatous leprosy (LL), borderline lepromatous leprosy (BL), and histoid leprosy tested positive for Fite-faraco. 55% of instances showed clinico-pathological concordance.
Conclusion: Fite-faraco staining and histopathological analysis are advised in all clinically suspected leprosy cases in order to aid in precise leprosy subtyping and diagnosis.
Keywords: Leprosy, Clinico-pathological, Fite-faraco stain, Skin biopsy.
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How to Cite This Article
Vancouver
Parmar SP, Mavadiya S. A cross-sectional study of clinicopathological patterns in leprosy patients in a tertiary care centre [Internet]. IP J Diagn Pathol Oncol. 2025 [cited 2025 Oct 07];10(2):66-70. Available from: https://doi.org/10.18231/j.jdpo.2025.015
APA
Parmar, S. P., Mavadiya, S. (2025). A cross-sectional study of clinicopathological patterns in leprosy patients in a tertiary care centre. IP J Diagn Pathol Oncol, 10(2), 66-70. https://doi.org/10.18231/j.jdpo.2025.015
MLA
Parmar, Shivani Pravinchandra, Mavadiya, Shashikant. "A cross-sectional study of clinicopathological patterns in leprosy patients in a tertiary care centre." IP J Diagn Pathol Oncol, vol. 10, no. 2, 2025, pp. 66-70. https://doi.org/10.18231/j.jdpo.2025.015
Chicago
Parmar, S. P., Mavadiya, S.. "A cross-sectional study of clinicopathological patterns in leprosy patients in a tertiary care centre." IP J Diagn Pathol Oncol 10, no. 2 (2025): 66-70. https://doi.org/10.18231/j.jdpo.2025.015