Peripheral Hemophagocytosis- A key to decifer Hemophagocytic lymphohistiocytosis, an extremely rare case report

• DR SWATI RAJ*

Abstract

Hemophagocytic lymphohistiocytosis(HLH) is a rare disease and unlikely under-recognised, which is an emergency to treat the patient as it carries high and fast mortality. The diagnosis of HLH is solely based on current criteria HLH -2007 (updated version of HLH-2004), 5 out of 8 criteria must be met for its laboratory diagnosis. As per the best of our knowledge, only 6 cases of HLH presented as peripheral finding documented online and no case found to report in India. We present an extremely rare case of an adult male in his 30s from India, clinically presented with high grade fever, weakness, oligouria and slurring of speech since 20 days. On routine screening of PBS in order to correct CBC revealed peripheral circulating hemophagocytic histiocytes and further testing was advised as suspicion of HLH was taken into account. Total 6 out of 8 diagnostic criteria were met and a confirmed diagnosis of HLH was made.

Keywords

Histiocytes, Hemophagocytic Lymphohistiocytosis ,Peripheral Blood Smear,HLH Diagnostic Criteria