Title: The Effect of the Gut Microbiome on Obesity: Mechanisms, Interactions, and Therapeutic Implications: A Comprehensive Review

Tejashwini Kotian,*
Ravi Gupta

Abstract

Discovery of the gut microbiome as a crucial element in obesity. Recent research has not only linked changes to the gut microflora with development of obesity but also provided novel insights into it pathophysiology. Here we present a review paper with the latest highlights on how microbiota contribute to obesity and unravel possible molecular mechanisms by which gut microorganisms can modulate energy balance, metabolic control of body weight homeostasis and inflammation. Furthermore, we investigate the crosstalk of diet with genetics and microbiome in obesity pathophysiology as well as the gut–brain axis related to metabolic regulation, and consider future implications from this knowledge for management of obesity.